Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss
is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of …

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate
and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is …

Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

The translation of messenger RNAs (mRNAs) into proteins is a key event in the regulation of
gene expression. This is especially true in the cancer setting, as many oncogenes and …

RNA helicases of the DEAD box family are present in all eukaryotic cells and in many
bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism …

The large serine/threonine protein kinase mTOR regulates cellular and organismal
homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and …

Translational control in eukaryotic cells is critical for gene regulation during nutrient
deprivation and stress, development and differentiation, nervous system function, aging, and …

The process of translation requires substantial cellular resources. Cells have therefore
evolved complex mechanisms to control overall protein synthesis as well as the translation …

Elevated protein synthesis is an important feature of many cancer cells and often arises as a
consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F) …