Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

Host immune response against Mycobacterium tuberculosis is mediated by cellular
immunity, in which cytokines and Th1 cells play a critical role. In the process of control of the …

A major challenge in tuberculosis control is the diagnosis and treatment of latent
tuberculosis infection. Until recently, there were no alternatives to the tuberculin skin test …

Tuberculosis (TB) is an international public health priority and kills almost two million people
annually. TB is out of control in Africa due to increasing poverty and HIV coinfection, and …

The lethality of Mycobacterium tuberculosis remains the highest among infectious organisms
and is linked to inadequate immune response of the host. Containment and cure of …

Tuberculosis (TB) continues to ravage humanity, causing 2 million deaths per year. A
vaccine against TB more potent than the current live vaccine, bacillus Calmette–Guérin …

Resolution of infections depends on the host's ability to mount a protective immune
response. However, an exacerbated response to infections may result in deleterious lesions …

The wide spectrum of clinical outcomes following infection with Mycobacterium tuberculosis
is largely determined by the host immune response; therefore, we studied several clinically …