Humans have been increasingly recognized as being superorganisms, living in close
contact with a microbiota on all their mucosal surfaces. However, most studies on the human …

Francisella tularensis is a facultative intracellular gram-negative pathogen and the
etiological agent of the zoonotic disease tularemia. Recent advances in the field of …

Bacteria with two cell membranes (diderms) have evolved complex systems for protein
secretion. These systems were extensively studied in some model bacteria, but the …

Francisella tularensis, the causative agent of tularemia, is one of the most infectious
bacterial pathogens known and is a category A select agent. We created a sequence …

Francisella tularensis has been recognized as the causative agent of tularaemia for almost a
century. Since its discovery in 1911, it has been shown to infect a wide range of hosts …

Protein glycosylation is an important posttranslational modification that occurs in all domains
of life. Pilins, the structural components of type IV pili, are O glycosylated in Neisseria …

Francisella tularensis are the causative agent of the zoonotic disease, tularaemia. Among
four F. tularensis subspecies, ssp. novicida (F. novicida) is pathogenic only for …

Background Francisella tularensis is a zoonotic intracellular bacterial pathogen that causes
tularemia. The subspecies tularensis is highly virulent and is classified as a category A …

Francisella tularensis is a highly-infectious bacterium that causes the rapid, and often lethal
disease, tularemia. Many studies have been performed to identify and characterize the …

Francisella tularensis, the highly virulent etiologic agent of tularemia, is a low-dose
intracellular pathogen that is able to escape from the phagosome and replicate in the …