The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …

In a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …

TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4
not only engages with exogenous ligands at the cellular membrane's surface but also …

Trained immunity is a de facto memory for innate immune responses, leading to long-term
functional reprogramming of innate immune cells. In physiological conditions, trained …

Duchenne muscular dystrophy (DMD) is a severe, progressive, and ultimately fatal disease
of skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. The identification …

Alzheimer's disease (AD) is the most prevalent cause of dementia; microglia have been
implicated in AD pathogenesis, but their role is still matter of debate. Our study showed that …

For almost nearly a century, memory functions have been attributed only to acquired
immune cells. Lately, this paradigm has been challenged by an increasing number of …

α1, 6-Fucosyltransferase (Fut8) is the enzyme responsible for catalyzing core fucosylation.
Exogenous L-fucose upregulates fucosylation levels through the GDP-fucose salvage …

Cancer vaccines hold great potential for clinical cancer treatment by eliciting T cell‐
mediated immunity. However, the limited numbers of antigen‐presenting cells (APCs) at the …

The acute inflammatory response is an inherent protective mechanism, and its unsuccessful
resolution can contribute to disease pathogenesis and potentially lead to death. Innate …