Understanding the evolutionary and ecological roles of'non-genetic'inheritance (NGI) is
daunting due to the complexity and diversity of epigenetic mechanisms. We draw on insights …

Chromatin is organized and compacted in the nucleus through the association of histones
and other proteins, which together control genomic activity. Two broad types of chromatin …

The chromatin regulator FACT (facilitates chromatin transcription) is essential for ensuring
stable gene expression by promoting transcription. In a genetic screen using Caenorhabditis …

Due to short life cycle, nematode Caenorhabditis elegans is a suitable animal model for
assessing the effect of long-term simulated microgravity treatment on organisms. We here …

Stem cell systems are essential for the development and maintenance of polarized tissues.
Intercellular signaling pathways control stem cell systems, where niche cells signal stem …

Understanding transdifferentiation—the conversion of one differentiated cell type into
another—is important from both basic science and clinical perspectives. In Caenorhabditis …

Nanos RNA-binding proteins are required for germline development in metazoans, but the
underlying mechanisms remain poorly understood. We have profiled the transcriptome of …

Chromatin regulators play important roles in the safeguarding of cell identities by opposing
the induction of ectopic cell fates and, thereby, preventing forced conversion of cell identities …

Maternally synthesized products play critical roles in the development of offspring. A premier
example is the Caenorhabditis elegans H3K36 methyltransferase MES-4, which is essential …

While Caenorhabditis elegans was originally regarded as a model for investigating
determinate developmental programs, landmark studies have subsequently shown that the …