The Myc proteins comprise a family of ubiquitous regulators of gene expression implicated
in over half of all human cancers. They interact with a large number of other proteins, such …

Conformational changes of catalytically-important structural elements are a key feature of
the regulation mechanisms of protein kinases and are important for dictating inhibitor …

Structural changes involved in protein kinase activation and ligand binding have been
determined from a wealth of X-ray crystallographic evidence. Recent solution studies using …

Conformational transitions in protein kinases are crucial for the biological function of these
enzymes. Here, we characterize and assess conformational equilibria of the activation loop …

Electron paramagnetic resonance (EPR) spectroscopy in combination with site-directed spin
labeling (SDSL) is a powerful approach to supplement the large toolbox of methods for …