Amyloid plaques, mainly composed of abnormally aggregated amyloid β-protein (Aβ) in the
brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau …

Toll-like receptors (TLRs) are discovered as crucial pattern recognition receptors (PRRs)
involved in the recognition of pathogen-associated molecular patterns (PAMPs). Later …

Glial cells have a variety of functions in the brain, ranging from immune defense against
external and endogenous hazardous stimuli, regulation of synaptic formation, calcium …

Toll-like receptors (TLRs) are a group of receptors widely distributed in the organism. In the
central nervous system, they are expressed in neurons, astrocytes and microglia. Although …

Alzheimer's disease (AD) is a major public health problem with substantial economic and
social impacts around the world. The hallmarks of AD pathogenesis include deposition of …

J. Neurochem.(2012) 120, 461–472. Abstract Activation of microglia, the resident
macrophages of the brain, around the amyloid plaques is a key hallmark of Alzheimer's …

Generation of neurotoxic amyloid β peptides and their deposition along with neurofibrillary
tangle formation represent key pathological hallmarks in Alzheimer's disease (AD). Recent …

Toll‐like receptors (TLRs) or pattern recognition receptors respond to pathogen‐associated
molecular patterns (PAMPs) or internal damage‐associated molecular patterns (DAMPs) …

Deposits of amyloid β-protein (Aβ) in neuritic plaques and cerebral vessels are a
pathological hallmark of Alzheimer's disease. Fibrillar Aβ deposits are closely associated …

The formyl peptide receptor (FPR) family is involved in host defence against pathogens, but
also in sensing internal molecules that may constitute signals of cellular dysfunction. It …