Quantitative proteomic profiling in brain subregions of mice exposed to open-field low-intensity blast reveals position-dependent blast effects

M Jackson, S Chen, P Liu, M Langenderfer, C Li… - Shock Waves, 2024 - Springer
The neurological consequences of combat blast-induced neurotrauma (BINT) pose
important clinical concerns for military service members and veterans. Previous studies have …

Investigation of the direct and indirect mechanisms of primary blast insult to the brain

JE Rubio, G Unnikrishnan, VSSS Sajja, S Van Albert… - Scientific reports, 2021 - nature.com
The interaction of explosion-induced blast waves with the head (ie, a direct mechanism) or
with the torso (ie, an indirect mechanism) presumably causes traumatic brain injury …

Limbic responses following shock wave exposure in male and female mice

EH McNamara, LB Tucker, J Liu, AH Fu… - Frontiers in Behavioral …, 2022 - frontiersin.org
Blast traumatic brain injury (bTBI) presents a serious threat to military personnel and often
results in psychiatric conditions related to limbic system dysfunction. In this study, the …

A biomechanical-based approach to scale blast-induced molecular changes in the brain

JE Rubio, DR Subramaniam, G Unnikrishnan… - Scientific Reports, 2022 - nature.com
Animal studies provide valuable insights on how the interaction of blast waves with the head
may injure the brain. However, there is no acceptable methodology to scale the findings …

Characterization of an Advanced Blast Simulator for Investigation of Large Scale Blast Traumatic Brain Injury Studies

AJ Nelson, D Ritzel, N Showalter, D Boppe… - Annals of Biomedical …, 2024 - Springer
Blast traumatic brain injury (bTBI) is a prominent military health concern. The pervasiveness
and long-term impacts of this injury highlight the need for investigation of the physiological …

Cerebral vasculature influences blast-induced biomechanical responses of human brain tissue

DR Subramaniam, G Unnikrishnan… - … in bioengineering and …, 2021 - frontiersin.org
Multiple finite-element (FE) models to predict the biomechanical responses in the human
brain resulting from the interaction with blast waves have established the importance of …

Spatial intracranial pressure fields driven by blast overpressure in rats

C Norris, SF Murphy, CE Talty… - Annals of biomedical …, 2024 - Springer
Free-field blast exposure imparts a complex, dynamic response within brain tissue that can
trigger a cascade of lasting neurological deficits. Full body mechanical and physiological …

A 3-D finite-element minipig model to assess brain biomechanical responses to blast exposure

A Sundaramurthy, VB Kote, N Pearson… - … in Bioengineering and …, 2021 - frontiersin.org
Despite years of research, it is still unknown whether the interaction of explosion-induced
blast waves with the head causes injury to the human brain. One way to fill this gap is to use …

Effect of blast orientation, multi-point blasts, and repetitive blasts on brain injury

S Duan, Z Wang, W Zhang, Y Lu, G Ma - Medical Engineering & Physics, 2024 - Elsevier
Explosions in the battlefield can result in brain damage. Research on the effects of shock
waves on brain tissue mainly focuses on the effects of single-orientation blast waves, while …

Shock wave damage from the ventral side in primary blast injury: An experimental study in pigs

N Kiriu, D Saitoh, Y Sekine, K Yamamura, R Sasa… - Injury, 2024 - Elsevier
Abstract Aim/Purpose This study aimed to apply a shock wave from the ventral side of a pig
and examine its effect to use the results for new body armor production for humans. Methods …