[PDF][PDF] Ovarian microenvironment: challenges and opportunities in protecting against chemotherapy-associated ovarian damage

Y Guo, L Xue, W Tang, J Xiong, D Chen… - Human …, 2024 - academic.oup.com
BACKGROUND Chemotherapy-associated ovarian damage (CAOD) is one of the most
feared short-and long-term side effects of anticancer treatment in premenopausal women …

Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy

J Wu, Y Tang, X Liang - OncoTargets and therapy, 2018 - Taylor & Francis
Vascular normalization is a new concept of targeting angiogenesis to restore vessel
structure and function and to increase blood perfusion and delivery of drugs. It has been …

Hypoxia up-regulates VEGF ligand and downregulates VEGF soluble receptor mRNA expression in bovine granulosa cells in vitro

J Hernández-Morales, CG Hernández-Coronado… - Theriogenology, 2021 - Elsevier
Abstract Oxygen concentration (0 2) in antral ovarian follicles is below that found in most
tissues, which is important for adequate granulosa cell function. The VEGF system is linked …

[PDF][PDF] Estradiol supports in vitro development of bovine early antral follicles

M Endo, R Kawahara-Miki, F Cao, K Kimura… - …, 2013 - researchgate.net
Antrum formation and estradiol (E2) secretion are specific features of oocyte and granulosa
cell complexes (OGCs). This study investigates the effect of E2 on the in vitro development of …

Amount of mRNA and localization of vascular endothelial growth factor and its receptors in the ovarian follicle during estrous cycle of water buffalo (Bubalus bubalis)

V Babitha, RP Panda, VP Yadav, VS Chouhan… - Animal Reproduction …, 2013 - Elsevier
The objective of the present study was to characterize the temporal patterns of gene
expression for vascular endothelial growth factors (VEGF) and VEGF receptors during …

A review on inflammation and angiogenesis as key mechanisms involved in the pathogenesis of bovine cystic ovarian disease

AF Stassi, PU Díaz, FB Gasser, MML Velázquez… - Theriogenology, 2022 - Elsevier
Cystic ovarian disease (COD) is an important cause of reproductive failure in dairy cattle.
The main aim of this review is to discuss some aspects related to inflammation and …

Study on 20-hydroxyprogesterone: Chiral resolution, content determination and progesterone-like activity

Y Cheng, S Yan, L Li, S Du, C Zhong, X Gao… - The Journal of Steroid …, 2024 - Elsevier
hydroxyprogesterone (20-DHP) is a natural metabolite of progesterone which occurs with
two diastereoisomers: 20α-DHP and 20β-DHP. They have drawn attention for their …

The vascular endothelial growth factor (VEGF) system as a key regulator of ovarian follicle angiogenesis and growth

A Guzmán, CG Hernández‐Coronado… - Molecular …, 2023 - Wiley Online Library
The vascular endothelial growth factor‐A (VEGFA) system is a complex set of proteins, with
multiple isoforms and receptors, including both angiogenic (VEGFxxx, VEGFR2) and …

Sphingosine-1-phosphate and ceramide are associated with health and atresia of bovine ovarian antral follicles

CG Hernández-Coronado, A Guzmán… - animal, 2015 - cambridge.org
The follicle destiny towards ovulation or atresia is multi-factorial in nature and involves
outcries, paracrine and endocrine factors that promote cell proliferation and survival …

Reduction in the mRNA expression of sVEGFR 1 and sVEGFR 2 is associated with the selection of dominant follicle in cows

PV Ortega Serrano, A Guzmán… - … in Domestic Animals, 2016 - Wiley Online Library
Contents The vascular endothelial growth factor (VEGF) is essential for follicular
development by promoting follicular angiogenesis, as well as for the proliferation and …