Pioneer of prostate cancer: past, present and the future of FOXA1
Prostate cancer is the most commonly diagnosed non-cutaneous cancers in North American
men. While androgen deprivation has remained as the cornerstone of prostate cancer …
men. While androgen deprivation has remained as the cornerstone of prostate cancer …
Shaping chromatin states in prostate cancer by pioneer transcription factors
The androgen receptor (AR) is a critical therapeutic target in prostate cancer that responds
to antagonists in primary disease, but inevitably becomes reactivated, signaling onset of the …
to antagonists in primary disease, but inevitably becomes reactivated, signaling onset of the …
[HTML][HTML] Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer
Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …
A genomic and epigenomic atlas of prostate cancer in Asian populations
J Li, C Xu, HJ Lee, S Ren, X Zi, Z Zhang, H Wang, Y Yu… - Nature, 2020 - nature.com
Prostate cancer is the second most common cancer in men worldwide. Over the past
decade, large-scale integrative genomics efforts have enhanced our understanding of this …
decade, large-scale integrative genomics efforts have enhanced our understanding of this …
SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1
Dysregulation of histone lysine methyltransferases and demethylases is one of the major
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …
FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer
FOXA family proteins act as pioneer factors by remodeling compact chromatin structures.
FOXA1 is crucial for the chromatin binding of the androgen receptor (AR) in both normal …
FOXA1 is crucial for the chromatin binding of the androgen receptor (AR) in both normal …
RB1 loss in castration-resistant prostate cancer confers vulnerability to LSD1 inhibition
Genomic loss of RB1 is a common alteration in castration-resistant prostate cancer (CRPC)
and is associated with poor patient outcomes. RB1 loss is also a critical event that promotes …
and is associated with poor patient outcomes. RB1 loss is also a critical event that promotes …
Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer
Prostate cancer is the second most commonly diagnosed malignancy among men
worldwide. Recurrently mutated in primary and metastatic prostate tumors, FOXA1 encodes …
worldwide. Recurrently mutated in primary and metastatic prostate tumors, FOXA1 encodes …
Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations
S Dai, L Qu, J Li, Y Chen - Nucleic acids research, 2021 - academic.oup.com
Forkhead box (FOX) proteins are an evolutionarily conserved family of transcription factors
that play numerous regulatory roles in eukaryotes during developmental and adult life …
that play numerous regulatory roles in eukaryotes during developmental and adult life …
Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential
J Kneppers, TM Severson, JC Siefert, P Schol… - Nature …, 2022 - nature.com
Androgen receptor (AR) drives prostate cancer (PCa) development and progression. AR
chromatin binding profiles are highly plastic and form recurrent programmatic changes that …
chromatin binding profiles are highly plastic and form recurrent programmatic changes that …