This article summarizes the likely benefits of melatonin in the attenuation of COVID-19
based on its putative pathogenesis. The recent outbreak of COVID-19 has become a …

Exogenous melatonin has been investigated as treatment for a number of medical and
surgical diseases, demonstrating encouraging results. The aim of this review was to present …

Purpose Delirium is common in the critically ill, highly distressing to patients and families
and associated with increased morbidity and mortality. Results of studies on preventative …

Purpose The aim of the review was to provide an overview of studies investigating the
pharmacokinetics of exogenous melatonin in humans and if possible, to provide …

This review aims at describing the beneficial properties of melatonin related to its antioxidant
effects. Oxidative stress, ie, an imbalance between the production of reactive oxygen …

Despite treatment with therapeutic hypothermia, almost 50% of infants with neonatal
encephalopathy still have adverse outcomes. Additional treatments are required to …

The neurohormone N-acetyl-5-methoxytryptamine, better known as melatonin, is a
tryptophan derivative with a wide range of biological effects that is present in many …

Persistent physical impairment is frequently encountered after critical illness. Recent data
point towards mitochondrial dysfunction as an important determinant of this phenomenon …

Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO),
and despite decades of research, novel initiatives are drastically needed. According to the …

Sepsis is a massive inflammatory response mediated by infection, characterized by
oxidative stress, release of cytokines, and mitochondrial dysfunction. Melatonin accumulates …