Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

The heart is lined by a single layer of mesothelial cells called the epicardium that provides
important cellular contributions for embryonic heart formation. The epicardium harbors a …

Cellular switching from an epithelial-to-mesenchymal phenotype, and conversely from a
mesenchymal-toepithelial phenotype, are important biological programs that are operative …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Serum response factor (SRF) is a widely expressed transcription factor involved in
orchestrating disparate programs of gene expression linked to muscle differentiation and …

Rationale: In early heart development, platelet-derived growth factor (PDGF) receptor
expression in the heart ventricles is restricted to the epicardium. Previously, we showed that …

Xenopus embryos provide a rich source of pluripotent cells that can be differentiated into
functional organs. Since the molecular principles of vertebrate organogenesis appear to be …

Extensive studies over the last 30 years have demonstrated that vascular smooth muscle
cell (SMC) differentiation and phenotypic modulation is controlled by a dynamic array of …

Mesenchymal stem cell (MSC) therapy has demonstrated applications in vascular
regenerative medicine. Although blood vessels exist in a mechanically dynamic …

The nuclear p68 RNA helicase (referred to as p68) is a prototypical member of the DEAD
box family of RNA helicases. The protein plays a very important role in early organ …