Neuropeptides (NPs) are key signaling molecules that interact with G protein-coupled
receptors, influencing neuronal activities and developmental pathways, as well as the …

Over a decade of genome-wide association, studies have made great strides toward the
detection of genes and genetic mechanisms underlying complex traits. However, the …

Definitive molecular diagnoses in disorders apparently due to genetic or genomic defects
are still lacking in a significant number of investigated cases, despite use of studies …

The completion of the sequencing of the human, mouse, and other genomes has allowed
efforts to annotate these genomes extensively using a combination of computational and …

Background Alzheimer's disease, the most common form of dementia, accounts for 60–80%
of cases and its prevalence is projected to increase as aging populations grow. By 2050, the …

The recent progress of genomics research is providing unprecedented insight into human
genetic variance, susceptibility to disease and risk stratification. Current trends predict that a …

The Hedgehog (Hh) signaling pathway directs a multitude of cellular responses during
embryogenesis and adult tissue homeostasis. Stimulation of the pathway results in …

Abstract Background Transcription factors (TFs) play central roles in maintaining “stemness”
of embryonic stem (ES) cells and their differentiation into several hundreds of adult cell …

Taurine, an amino sulfonic acid that is sometimes referred to as an amino acid, is
endogenously synthesized by the action of the key genes/enzymes: cysteine dioxygenase …

Uncovering and mathematically modeling Transcription Factor Networks (TFNs) are the first
steps in engineering plants with traits that are better equipped to respond to changing …