T-cell exhaustion is a phenomenon of dysfunction or physical elimination of antigen-specific T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
A Thakur, H Mikkelsen… - Journal of immunology …, 2019 - Wiley Online Library
Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites are ranked as the second leading cause of death worldwide by the World Health …
BP Keenan, L Fong, RK Kelley - Journal for immunotherapy of cancer, 2019 - Springer
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors …
T Tian, Z Li - Frontiers in oncology, 2021 - frontiersin.org
Programmed death receptor 1 (PD-1) or programmed death ligand 1 (PD-L1) blocking therapy has completely changed the treatment pattern of malignant tumors. It has been …
M Duan, S Goswami, JY Shi, LJ Wu, XY Wang… - Clinical Cancer …, 2019 - AACR
Purpose: Innate immunity is an indispensable arm of tumor immune surveillance, and the liver is an organ with a predominance of innate immunity, where mucosal-associated …
Z Meng, Y Chen, M Lu - Frontiers in Immunology, 2020 - frontiersin.org
“Functional cure” is being pursued as the ultimate endpoint of antiviral treatment in chronic hepatitis B (CHB), which is characterized by loss of HBsAg whether or not anti-HBs …
CK Vorkas, C Krishna, K Li, J Aube… - The Journal of …, 2022 - journals.aai.org
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that recognize microbial vitamin B metabolites and have emerging roles in infectious disease …
H Mehta, MJ Lett, P Klenerman… - Seminars in …, 2022 - Springer
Mucosal-associated invariant T cells or MAIT cells are an abundant cell type in humans and especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge …
CP Hackstein, P Klenerman - Seminars in Immunology, 2022 - Elsevier
MAIT cells are one representative of a group of related unconventional or pre-set T cells, and are particularly abundant in humans. While these unconventional T cell types, which …