Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system
S Gritsch, TT Batchelor, LN Gonzalez Castro - Cancer, 2022 - Wiley Online Library
The 2016 revised fourth edition of the World Health Organization (WHO) classification of
central nervous system (CNS) tumors incorporated molecular features with histologic …
central nervous system (CNS) tumors incorporated molecular features with histologic …
Challenges to curing primary brain tumours
Despite decades of research, brain tumours remain among the deadliest of all forms of
cancer. The ability of these tumours to resist almost all conventional and novel treatments …
cancer. The ability of these tumours to resist almost all conventional and novel treatments …
cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading
Abstract cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to
CNS Tumor Taxonomy) was established to evaluate and make practical recommendations …
CNS Tumor Taxonomy) was established to evaluate and make practical recommendations …
The landscape of genomic alterations across childhood cancers
SN Gröbner, BC Worst, J Weischenfeldt, I Buchhalter… - Nature, 2018 - nature.com
Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …
The Hippo signaling pathway in development and disease
The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …
has been implicated in an increasing number of human diseases, including cancer. Here …
Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
WHO 2016 Classification of gliomas
P Wesseling, D Capper - Neuropathology and applied …, 2018 - Wiley Online Library
Gliomas are the most frequent intrinsic tumours of the central nervous system and
encompass two principle subgroups: diffuse gliomas and gliomas showing a more …
encompass two principle subgroups: diffuse gliomas and gliomas showing a more …
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled
with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute …
with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute …
The 2016 World Health Organization classification of tumors of the central nervous system: a summary
Abstract The 2016 World Health Organization Classification of Tumors of the Central
Nervous System is both a conceptual and practical advance over its 2007 predecessor. For …
Nervous System is both a conceptual and practical advance over its 2007 predecessor. For …
Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience
Recently, we described a machine learning approach for classification of central nervous
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …