Healthcare‐associated infections due to multidrug‐resistant Gram‐negative bacteria (MDR‐
GNB) are a leading cause of morbidity and mortality worldwide. These evidence‐based …

Extended-spectrum β-lactamases (ESBLs) are a rapidly evolving group of β-lactamases
which share the ability to hydrolyze third-generation cephalosporins and aztreonam yet are …

This report updates, expands, and replaces the previously published CDC" Guideline for
Prevention of Nosocomial Pneumonia". The new guidelines are designed to reduce the …

In 1987 we reviewed the literature on the concept of colonization resistance (CR)(12). In this
concept, the indige-nous anaerobic flora limits the concentration of potentially pathogenic …

The need to stem the growing problem of antimicrobial resistance has prompted multiple,
sometimes conflicting, calls for changes in the use of antimicrobial agents. One source of …

Antimicrobial resistance has emerged as an important determinant of outcome for patients in
the intensive care unit (ICU). This is largely due to the administration of inadequate …

Nosocomial infections (NIs) now concern 5 to 15% of hospitalized patients and can lead to
complications in 25 to 33% of those patients admitted to ICUs. The most common causes are …

Study objective The purpose of this study was to test the effectiveness of oropharyngeal
decontamination on nosocomial infections in a comparatively homogeneous population of …

Traditional infection control measures in intensive care units (ICUs) have been directed at
limiting person to person spread of infection and improving care of invasive devices. These …

Objective To evaluate the effect of oral decontamination on the incidence of ventilator
associated pneumonia and mortality in mechanically ventilated adults. Design Systematic …