Di-(2-Ethylhexyl) phthalate and microplastics induced neuronal apoptosis through the PI3K/AKT pathway and mitochondrial dysfunction

W Zhang, X Sun, X Qi, X Liu, Y Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Di-(2-Ethylhexyl) phthalate (DEHP) and microplastics (MPs) have released widespread
residues to the environment and possess the ability to cause damage to humans and …

Investigation of the anti-cancer potential of epoxyazadiradione in neuroblastoma: experimental assays and molecular analysis

S Chandel, A Bhattacharya, A Gautam… - Journal of …, 2024 - Taylor & Francis
Neuroblastoma, the most common childhood solid tumor, originates from primitive
sympathetic nervous system cells. Epoxyazadiradione (EAD) is a limonoid derived from …

Glucogallin attenuates the LPS-induced signaling in macrophages and protects mice against Sepsis

R Singh, S Chandel, A Ghosh, T Matta… - International Journal of …, 2022 - mdpi.com
The anti-oxidant and anti-inflammatory effect of beta-glucogallin (BGG), a plant-derived
natural product, was evaluated in both in vitro and in vivo studies. For the in vitro study, the …

(8-Hydroxyquinoline) Gallium (III) Complex with High Antineoplastic Efficacy for Treating Colon Cancer via Multiple Mechanisms

SH Zhou, WH Liao, Y Yang, W Li, Y Wu, TT Wu… - ACS …, 2023 - ACS Publications
A series of (8-hydroxyquinoline) gallium (III) complexes (CP-1–4) was synthesized and
characterized by single X-ray crystallography and density functional theory (DFT) …

In-vitro and in-vivo studies of two-drug cocktail therapy targeting chemobrain via the Nrf2/NF-κB signaling pathway

A Singh, V Kumar, U Langeh, L Kapil, S Kaur… - Journal of Molecular …, 2024 - Springer
Today, we critically need alternative therapeutic options for chemotherapy-induced cognitive
impairment (CICI), often known as chemo brain. Mitochondrial dysfunction and oxidative …

Multistage in silico approach to identify novel quinoline derivatives as potential c-kit kinase inhibitors

S Gupta, M Saha, R Singh, SB Ahmed… - Journal of Biomolecular …, 2024 - Taylor & Francis
Abstract The type II-C-KIT signaling network has been extensively studied for its potential as
a target for cancer treatment, leading to the investigation of quinoline derivatives as …

[HTML][HTML] Role of Hypoxia Induced by Medicinal Plants; A Revolutionary Era of Cellular and Molecular Herbal Medicine in Neuroblastoma Treatment

S Rahimi, F Shirin, M Moassesfar, H Zafari… - Frontiers in Bioscience …, 2024 - imrpress.com
As one of the most common solid pediatric cancers, Neuroblastoma (NBL) accounts for 15%
of all of the cancer-related mortalities in infants with increasing incidence all around the …

Molecular docking study of GSK‐3β interaction with nomilin, kihadanin B, and related limonoids and triterpenes with a furyl‐δ‐lactone core

G Vergoten, C Bailly - Journal of Biochemical and Molecular …, 2022 - Wiley Online Library
Glycogen synthase kinase‐3β (GSK‐3β) is a target enzyme considered for the treatment of
multiple human diseases, from neurodegenerative pathologies to viral infections and …

3, 5-Disubstituted-thiazolidine-2, 4-dione hybrids as antidiabetic agents: Design, synthesis, in-vitro and In vivo evaluation

G Singh, R Singh, V Monga, S Mehan - European Journal of Medicinal …, 2024 - Elsevier
Diabetes is one of the fastest-growing metabolic disorders, nearly doubling the number of
patients each year. There are different treatment approaches available for the management …

Design and synthesis of novel 3, 7-dihydro-1H-purine-2, 6-diones as DPP-4 inhibitors: An in silico, in vitro and in vivo approach

P Bisht, A Bhattacharya, A Pal, R Singh… - European Journal of …, 2024 - Elsevier
The inhibition of enzyme DPP-4 is pivotal for targeting type 2 diabetes mellitus (DM). The
study introduces two series of novel 1, 3-dimethyl-3, 7-dihydro-1H-purine-2, 6-diones …