TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Cannabinoid ligands targeting TRP channels

C Muller, P Morales, PH Reggio - Frontiers in molecular neuroscience, 2019 - frontiersin.org
Transient receptor potential (TRP) channels are a group of membrane proteins involved in
the transduction of a plethora of chemical and physical stimuli. These channels modulate ion …

Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history

SA Bonini, M Premoli, S Tambaro, A Kumar… - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance Cannabis sativa L.(C. sativa) is an annual dioecious plant,
which shares its origins with the inception of the first agricultural human societies in Asia …

Minor cannabinoids: biosynthesis, molecular pharmacology and potential therapeutic uses

KB Walsh, AE McKinney, AE Holmes - Frontiers in Pharmacology, 2021 - frontiersin.org
The medicinal use of Cannabis sativa L. can be traced back thousands of years to ancient
China and Egypt. While marijuana has recently shown promise in managing chronic pain …

Cannabis pharmacology: the usual suspects and a few promising leads

EB Russo, J Marcu - Advances in pharmacology, 2017 - Elsevier
The golden age of cannabis pharmacology began in the 1960s as Raphael Mechoulam and
his colleagues in Israel isolated and synthesized cannabidiol, tetrahydrocannabinol, and …

From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology

A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research

AA Izzo, M Teixeira, SPH Alexander… - British Journal of …, 2020 - Wiley Online Library
Natural products continue to be an important source of medicines and drug templates.
Indeed, it has been estimated that approximately a third of all Food and Drug Administration …

TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization

O Gouin, K L'herondelle, N Lebonvallet… - Protein & …, 2017 - academic.oup.com
Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …

Cannabis: Chemistry, extraction and therapeutic applications

F Pattnaik, S Nanda, S Mohanty, AK Dalai, V Kumar… - Chemosphere, 2022 - Elsevier
Cannabis, a genus of perennial indigenous plants is well known for its recreational and
medicinal activities. Cannabis and its derivatives have potential therapeutic activities to treat …

A review of hemp as food and nutritional supplement

P Cerino, C Buonerba, G Cannazza… - Cannabis and …, 2021 - liebertpub.com
The term “hemp” refers to Cannabis sativa cultivars grown for industrial purposes that are
characterized by lower levels of tetrahydrocannabinol (THC), the active principle …