Chagas disease and leishmaniasis are two neglected tropical diseases that affect millions of
people in low-and middle-income tropical countries. These diseases caused by protozoan …

A series of novel 5′-norcarbocyclic derivatives of 5-alkoxymethyl or 5-alkyltriazolyl-methyl
uracil were synthesized and the activity of the compounds evaluated against both Gram …

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial
therapies. Recent results from our laboratories from two structurally related scaffolds have …

A variety of ribo-, 2′-deoxyribo-, and 5′-norcarbocyclic derivatives of the 8-aza-7-
deazahypoxanthine fleximer scaffolds were designed, synthesized, and screened for …

Carbocyclic nucleoside analogues have a distinguished history as anti-infectious agents,
including key antiviral agents. Toxicity was initially a concern but this was reduced by the …

A new series of potential nonnucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs)
based on the carbocyclic 5′-nor-uracil scaffold were designed and synthesized. Three …

The pandemic caused by the novel betacoronavirus SARS-CoV-2 has already claimed more
than 3.5 million lives. Despite the development and use of anti-COVID-19 vaccines, the …

Several 5-aminouracil derivatives that have previously been shown to inhibit Mycobacterium
tuberculosis growth at concentrations of 5-40 μg/mL are demonstrated to act also as …

The present review briefly outlines main methods for the synthesis of 5′-norcarbocyclic
nucleoside analogs and the biological activity spectrum of these compounds. Antiviral …

Актуальность темы исследования. Одной из основных задач физико-химической
биологии и медицинской химии является создание новых эффективных препаратов …