Immunosenescence is a series of age-related changes that affect the immune system and,
with time, lead to increased vulnerability to infectious diseases. This Review addresses …

Immune regulation by cytokines is crucial in maintaining immune homeostasis, promoting
responses to infection, resolving inflammation, and promoting immunological memory …

CD8, but not CD4, T cells are considered critical for control of chronic toxoplasmosis.
Although CD8 exhaustion has been previously reported in Toxoplasma encephalitis (TE) …

Microsporidia are obligate intracellular and eukaryotic pathogens that can infect
immunocompromised and immunocompetent mammals, including humans. Both innate and …

Background: Cachexia is a metabolic disorder characterised by muscle wasting, diminished
response to anti-cancer treatments and poor quality of life. Our objective was to identify …

Objective To evaluate prognostic factors of patients with chordoma through a population-
based analysis. Methods Surveillance, Epidemiology, and End Results (SEER) database …

Chikungunya virus (CHIKV) is a re-emerging global pathogen with pandemic potential,
which causes fever, rash and debilitating arthralgia. Older adults over 65 years are …

By the last third of life, most mammals, including humans, exhibit a decline in immune cell
numbers, immune organ structure, and immune defense of the organism, commonly known …

Many observers have noted that the morphological changes that occur in chronic kidney
disease (CKD) patients resemble those seen in the geriatric population, with strikingly …

Aging, as a complex biological process, is accompanied by the accumulation of functional
loses at different levels, which makes age to be the biggest risk factor to many neurological …