Abstract Sp1 (specificity protein 1) is a well-known member of a family of transcription factors
that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential …

The heart is adapted to utilize all classes of substrates to meet the high-energy demand, and
it tightly regulates its substrate utilization in response to environmental changes. Although …

The Sp/KLF family contains at least twenty identi® ed members which include Sp1-4 and
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …

The initiation of transcription is accomplished via interactions of many different proteins with
common and gene-specific regulatory motifs. Clearly, sequence-specific transcription factors …

The heart is a unique organ in many ways. It consists of specialized muscle cells
(cardiomyocytes), which are adapted to contract constantly in a coordinated fashion. This is …

We used expression and reporter gene analysis to understand how changes in transcription
factors impinge on mitochondrial gene expression during myogenesis of cultured murine …

Neuregulins regulate the expression of acetylcholine receptor genes and induce
development of the neuromuscular junction in muscle. In studying whether neuregulins …

Glucose is a major source of energy for living organisms, and its transport in vertebrates is a
universally conserved property. Of all cell lineages, human erythrocytes express the highest …

Glucose is a major energy source for mammalian cells and is transported into cells via cell-
specific expression of various glucose transporters (GLUTs). Especially, cancer cells require …

Modification of chromatin structure by histone acetylases and deacetylases is an important
mechanism in modulation of eukaryotic gene transcription. The present study investigated …