Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal …

J Kindrachuk, B Ork, S Mazur… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus,
and infections with this virus can result in acute respiratory syndrome with renal failure …

Molecular characterization of breast cancer cell lines through multiple omic approaches

SE Smith, P Mellor, AK Ward, S Kendall… - Breast Cancer …, 2017 - Springer
Background Breast cancer cell lines are frequently used as model systems to study the
cellular properties and biology of breast cancer. Our objective was to characterize a large …

Integration of global analyses of host molecular responses with clinical data to evaluate pathogenesis and advance therapies for emerging and re-emerging viral …

SD Falcinelli, DS Chertow… - ACS infectious diseases, 2016 - ACS Publications
Outbreaks associated with emerging and re-emerging viral pathogens continue to increase
in frequency and are associated with an increasing burden to global health. In light of this …

Technological advances for interrogating the human kinome

A Baharani, B Trost, A Kusalik… - Biochemical Society …, 2017 - portlandpress.com
There is increasing appreciation among researchers and clinicians of the value of
investigating biology and pathobiology at the level of cellular kinase (kinome) activity …

Mycobacterium avium subsp. paratuberculosis inhibits gamma interferon-induced signaling in bovine monocytes: insights into the cellular mechanisms of Johne's …

RJ Arsenault, Y Li, K Bell, K Doig, A Potter… - Infection and …, 2012 - Am Soc Microbiol
Mycobacterium avium subsp. paratuberculosis is the causative agent of Johne's disease in
cattle and may have implications for human health. Establishment of chronic infection by M …

In Vitro Infection of Bovine Monocytes with Mycoplasma bovis Delays Apoptosis and Suppresses Production of Gamma Interferon and Tumor Necrosis Factor Alpha …

M Mulongo, T Prysliak, E Scruten, S Napper… - Infection and …, 2014 - Am Soc Microbiol
Mycoplasma bovis is one of the major causative pathogens of bovine respiratory complex
disease (BRD), which is characterized by enzootic pneumonia, mastitis, pleuritis, and …

PIIKA 2: an expanded, web-based platform for analysis of kinome microarray data

B Trost, J Kindrachuk, P Määttänen, S Napper… - PloS one, 2013 - journals.plos.org
Kinome microarrays are comprised of peptides that act as phosphorylation targets for protein
kinases. This platform is growing in popularity due to its ability to measure phosphorylation …

[HTML][HTML] Butyrate and forskolin augment host defense, barrier function, and disease resistance without eliciting inflammation

K Robinson, Q Yang, H Li, L Zhang, B Aylward… - Frontiers in …, 2021 - frontiersin.org
Host defense peptides (HDPs) are an integral part of the innate immune system with both
antimicrobial and immunomodulatory activities. Induction of endogenous HDP synthesis is …

Supplementing chestnut tannins in the broiler diet mediates a metabolic phenotype of the ceca

A Lee, GC Dal Pont, MB Farnell, S Jarvis, M Battaglia… - Poultry science, 2021 - Elsevier
As the demand for alternatives to antibiotic growth promoters (AGP) increases in food animal
production, phytobiotic compounds gain popularity because of their ability to mimic the …

Chicken-Specific Kinome Array Reveals that Salmonella enterica Serovar Enteritidis Modulates Host Immune Signaling Pathways in the Cecum to Establish a …

MH Kogut, CL Swaggerty, JA Byrd, R Selvaraj… - International journal of …, 2016 - mdpi.com
Non-typhoidal Salmonella enterica induces an early, short-lived pro-inflammatory response
in chickens that is asymptomatic of clinical disease and results in a persistent colonization of …