Malaria is one of the most devastating infectious diseases of humans. It is problematic
clinically and economically as it prevails in poorer countries and regions, strongly hindering …

Discovery of a relict chloroplast (the apicoplast) in malarial parasites presented new
opportunities for drug development. The apicoplast–although no longer photosynthetic–is …

After the discovery of a potent natural flavonoid glucoside as a potent inhibitor of FabI, a
large flavonoid library was screened against three important enzymes (ie, FabG, FabZ, and …

Lipid metabolism is of crucial importance for pathogens. Lipids serve as cellular building
blocks, signalling molecules, energy stores, posttranslational modifiers, and pathogenesis …

Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called
apicoplast that is the most reduced organelle of this type known. Due to the medical …

The malaria parasite Plasmodium possesses a relict, non-photosynthetic plastid known as
the apicoplast. The apicoplast is essential for parasite survival, and harbors several plant …

The control and eventual eradication of human malaria is considered one of the most
important global public health goals of the 21st Century. Malaria, caused by intraerythrocytic …

Peony as an important medicinal material is widely cultivated in China, which is one of the
natural distribution centers of wild peony species. So far, however, there has not been a …

The modern approach to the development of new chemical entities against complex
diseases, especially the neglected endemic diseases such as tuberculosis and malaria, is …

Apicomplexan parasitic diseases impose devastating impacts on much of the world's
population. The increasing prevalence of drug resistant parasites and the growing number …