Strain improvement of Trichoderma harzianum for enhanced biocontrol capacity: Strategies and prospects

Z Xiao, Q Zhao, W Li, L Gao, G Liu - Frontiers in microbiology, 2023 - frontiersin.org
In the control of plant diseases, biocontrol has the advantages of being efficient and safe for
human health and the environment. The filamentous fungus Trichoderma harzianum and its …

Transcriptional activation of biosynthetic gene clusters in filamentous fungi

L Mózsik, R Iacovelli, RAL Bovenberg… - … in Bioengineering and …, 2022 - frontiersin.org
Filamentous fungi are highly productive cell factories, many of which are industrial
producers of enzymes, organic acids, and secondary metabolites. The increasing number of …

Role and genetic basis of specialised secondary metabolites in Trichoderma ecophysiology

I Vicente, R Baroncelli, R Hermosa, E Monte… - Fungal Biology …, 2022 - Elsevier
Species of fungal genus Trichoderma are characterized by a versatile lifestyle, high
adaptability to the changing environmental conditions and the ability to establish …

Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase

L Xie, X Zang, W Cheng, Z Zhang, J Zhou… - Journal of the …, 2021 - ACS Publications
Acetohydroxyacid synthase (AHAS) is the first enzyme in the branched-chain amino acid
biosynthetic pathway and is a validated target for herbicide and fungicide development …

[HTML][HTML] Trichoderma agriamazonicum sp. nov.(Hypocreaceae), a new ally in the control of phytopathogens

TF Sousa, BNPV Reça, GS Castro, IJS da Silva… - Microbiological …, 2023 - Elsevier
The genus Trichoderma comprises more than 500 valid species and is commonly used in
agriculture for the control of plant diseases. In the present study, a Trichoderma species …

The expanding CRISPR toolbox for natural product discovery and engineering in filamentous fungi

C Woodcraft, YH Chooi, I Roux - Natural Product Reports, 2023 - pubs.rsc.org
Covering: up to May 2022 Fungal genetics has transformed natural product research by
enabling the elucidation of cryptic metabolites and biosynthetic steps. The enhanced …

Enzymatic synthesis of fluorinated compounds

X Cheng, L Ma - Applied Microbiology and Biotechnology, 2021 - Springer
Fluorinated compounds are widely used in the fields of molecular imaging, pharmaceuticals,
and materials. Fluorinated natural products in nature are rare, and the introduction of …

Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes

E Skellam - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 1999 up to 2021 Fungal polyketides encompass a range of structurally diverse
molecules with a wide variety of biological activities. The giant multifunctional enzymes that …

Recent advances in genome mining and synthetic biology for discovery and biosynthesis of natural products

M Wang, L Chen, Z Zhang, Q Wang - Critical Reviews in …, 2025 - Taylor & Francis
Natural products have long served as critical raw materials in chemical and pharmaceutical
manufacturing, primarily which can provide superior scaffolds or intermediates for drug …

Assessing the Biosynthetic Inventory of the Biocontrol Fungus Trichoderma afroharzianum T22

W Han, Z Wu, Z Zhong, J Williams… - Journal of agricultural …, 2023 - ACS Publications
Natural products biosynthesized from biocontrol fungi in the rhizosphere can have both
beneficial and deleterious effects on plants. Herein, we performed a comprehensive …