Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Chromosomal region 9p21 containing tumor suppressors CDKN2A/B and
methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic deletions in …

Background & Aims Studies have reported abnormal gut microbiota or circulating
metabolome associated with colorectal cancer (CRC), but it remains a challenge to capture …

As a result of an increased focus on early detection including lung cancer screening,
combined with more curative treatment options, the five-year survival rates for lung cancer …

With the rising incidence of hepatocellular carcinoma (HCC) from non-alcoholic
steatohepatitis (NASH), identifying new metabolic readouts that function in metabolic …

In the era of histopathology-based diagnosis, the discrimination between multiple lung
cancers (MLCs) poses significant uncertainties and has thus become a clinical dilemma …

Objective The gut microbiota and its metabolites exert a significant influence on COPD, yet
the underlying mechanisms remain elusive. We aim to holistically evaluate the role and …

Serum samples from eight participants during the XV winter-over at Concordia base
(Antarctic expedition) collected at defined time points, including predeparture, constituted …

液体活检被逐渐应用于肺癌临床诊疗中。 目前， 随着代谢组学的发展， 越来越多代谢标志物被
认为是潜在的反映肿瘤发生发展的敏感标志物。 本文概括了肺癌主要代谢途径的改变 …

Background Surgery is the main curative therapeutic strategy for patients with initial primary
lung cancer (IPLC). Most international guidelines recommend regular follow-ups after …