[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation

NA Trayanova, A Lyon, J Shade… - Physiological …, 2023 - pmc.ncbi.nlm.nih.gov
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Fat infiltration in the infarcted heart as a paradigm for ventricular arrhythmias

E Sung, A Prakosa, S Zhou, RD Berger… - Nature cardiovascular …, 2022 - nature.com
Infiltrating adipose tissue (inFAT) has been recently found to co-localize with scar in
infarcted hearts and may contribute to ventricular arrhythmias (VAs), a life-threatening heart …

Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation

NA Trayanova, A Lyon, J Shade… - Physiological …, 2024 - journals.physiology.org
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Evaluation of an open-source pipeline to create patient-specific left atrial models: a reproducibility study

JA Solís-Lemus, T Baptiste, R Barrows, C Sillett… - Computers in Biology …, 2023 - Elsevier
This work presents an open-source software pipeline to create patient-specific left atrial
models with fibre orientations and a fibrDEFAULTosis map, suitable for electrophysiology …

A scalable framework for learning the geometry-dependent solution operators of partial differential equations

M Yin, N Charon, R Brody, L Lu, N Trayanova… - Nature Computational …, 2024 - nature.com
Solving partial differential equations (PDEs) using numerical methods is a ubiquitous task in
engineering and medicine. However, the computational costs can be prohibitively high …

Dimon: Learning solution operators of partial differential equations on a diffeomorphic family of domains

M Yin, N Charon, R Brody, L Lu, N Trayanova… - arXiv preprint arXiv …, 2024 - arxiv.org
The solution of a PDE over varying initial/boundary conditions on multiple domains is
needed in a wide variety of applications, but it is computationally expensive if the solution is …

Bayesian calibration of electrophysiology models using restitution curve emulators

S Coveney, C Corrado, JE Oakley… - Frontiers in …, 2021 - frontiersin.org
Calibration of cardiac electrophysiology models is a fundamental aspect of model
personalization for predicting the outcomes of cardiac therapies, simulation testing of device …

Computational modeling identifies embolic stroke of undetermined source patients with potential arrhythmic substrate

SF Bifulco, GD Scott, S Sarairah, Z Birjandian… - Elife, 2021 - elifesciences.org
Cardiac magnetic resonance imaging (MRI) has revealed fibrosis in embolic stroke of
undetermined source (ESUS) patients comparable to levels seen in atrial fibrillation (AFib) …

Fast characterization of inducible regions of atrial fibrillation models with multi-fidelity Gaussian process classification

L Gander, S Pezzuto, A Gharaviri, R Krause… - Frontiers in …, 2022 - frontiersin.org
Computational models of atrial fibrillation have successfully been used to predict optimal
ablation sites. A critical step to assess the effect of an ablation pattern is to pace the model …

Anti-and pro-fibrillatory effects of pulmonary vein isolation gaps in human atrial fibrillation digital twins

Z Jin, T Hwang, D Kim, B Lim, OS Kwon, S Kim… - npj Digital …, 2024 - nature.com
Although pulmonary vein isolation (PVI) gaps and extrapulmonary vein triggers contribute to
recurrence after atrial fibrillation (AF) ablation, their precise mechanisms remain unproven …