Hepatocellular carcinoma: new developments

P Ganesan, LM Kulik - Clinics in liver disease, 2023 - liver.theclinics.com
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality
worldwide and a leading cause of death in cirrhosis. The prognosis in HCC is poor, with …

Combination immunotherapy for hepatocellular carcinoma

L Rimassa, RS Finn, B Sangro - Journal of Hepatology, 2023 - Elsevier
Single-agent immune checkpoint inhibitors (ICIs) have been tested in patients with
advanced hepatocellular carcinoma (HCC), leading to objective response rates of 15-20 …

Critical appraisal of guideline recommendations on systemic therapies for advanced hepatocellular carcinoma: a review

S Cappuyns, V Corbett, M Yarchoan, RS Finn… - JAMA …, 2024 - jamanetwork.com
Importance The combination of immune checkpoint inhibitors with antiangiogenic agents
has revolutionized the treatment landscape of advanced hepatocellular carcinoma (HCC) …

TKIs in combination with immunotherapy for hepatocellular carcinoma

B Stefanini, L Ielasi, R Chen, C Abbati… - Expert review of …, 2023 - Taylor & Francis
Introduction The treatment landscape of hepatocellular carcinoma (HCC) has significantly
changed over the last 5 years with multiple options in the frontline, second line, and beyond …

AASLD practice guidance on risk stratification and management of portal hypertension and varices in cirrhosis

DE Kaplan, C Ripoll, M Thiele, BE Fortune… - Hepatology, 2024 - journals.lww.com
This Practice Guidance from the American Association for the Study of Liver Disease
(AASLD) intends to coalesce best practice recommendations for the identification of portal …

[HTML][HTML] Reproducible safety and efficacy of atezolizumab plus bevacizumab for HCC in clinical practice: Results of the AB-real study

CAM Fulgenzi, J Cheon, A D'Alessio, N Nishida… - European Journal of …, 2022 - Elsevier
Background IMbrave150 has established the superiority of atezolizumab plus bevacizumab
over sorafenib in patients with unresectable hepatocellular carcinoma (HCC). Methods We …

Immune checkpoint inhibitors in hepatocellular carcinoma: emerging challenges in clinical practice

M Pinter, B Scheiner, DJ Pinato - The lancet Gastroenterology & …, 2023 - thelancet.com
Systemic therapy for advanced hepatocellular carcinoma has expanded at an
unprecedented pace over the past 5 years. After tyrosine kinase inhibitors dominated the …

Immune checkpoint inhibitors for child-pugh class B advanced hepatocellular carcinoma: a systematic review and meta-analysis

E Xie, YH Yeo, B Scheiner, Y Zhang, A Hiraoka… - JAMA …, 2023 - jamanetwork.com
Importance Immune checkpoint inhibitors (ICIs) are increasingly used in patients with
advanced hepatocellular carcinoma (HCC). However, data on ICI therapy in patients with …

Updates on systemic therapy for hepatocellular carcinoma

P Ntellas, I Chau - American Society of Clinical Oncology Educational …, 2024 - ascopubs.org
This review explores the dynamic landscape of hepatocellular carcinoma (HCC) treatment,
emphasizing on recent developments across various stages and therapeutic approaches …

Effectiveness and safety of atezolizumab-bevacizumab in patients with unresectable hepatocellular carcinoma: a systematic review and meta-analysis

AV Kulkarni, H Tevethia, K Kumar, M Premkumar… - …, 2023 - thelancet.com
Background Atezolizumab-bevacizumab (atezo-bev) is recommended as first-line therapy
for patients with unresectable hepatocellular carcinoma (uHCC). However, its effectiveness …