Driver mutations promote initiation and progression of cancer. Pharmacological treatment
can inhibit the action of the mutant protein; however, drug resistance almost invariably …

Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Hypoxia, a hallmark of solid tumors, determines the selection of invasive and aggressive
malignant clones displaying resistance to radiotherapy, conventional chemotherapy or …

Chemotherapy remains a powerful tool to eliminate malignant cells. However, the efficacy of
chemotherapy is compromised by the frequent emergence of intrinsic and acquired …

Every sixth person in the world dies due to cancer, making it the second leading severe
cause of death after cardiovascular diseases. According to WHO, cancer claimed nearly 10 …

Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …

Lung cancer continues to be a malignant tumor with high mortality. Two obstacles interfere
with curative therapy of lung cancer:(i) poor diagnosis at the early stages, as symptoms are …

Entering a drug‐tolerant persister (DTP) state of cancer cells is a transient self‐adaptive
mechanism by which a residual cell subpopulation accelerates tumor progression. Here, we …

Resistance to the hypomethylating agents (HMAs) 5-azacytidine (AZA) and 5-aza-2′-
deoxycytidine (DAC) represents a major obstacle in the treatment of elderly patients with …

Lysosome-targeting self-assembling prodrugs had emerged as an attractive approach to
overcome the acquisition of resistance to chemotherapeutics by inhibiting lysosomal …