Epilepsy biomarkers–toward etiology and pathology specificity

A Pitkänen, XE Ndode-Ekane, N Lapinlampi… - Neurobiology of …, 2019 - Elsevier
A biomarker is a characteristic that is measured as an indicator of normal biologic
processes, pathogenic processes, or responses to an exposure or intervention, including …

MicroRNAs as regulators of brain function and targets for treatment of epilepsy

GP Brennan, DC Henshall - Nature Reviews Neurology, 2020 - nature.com
Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …

Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic …

H Geekiyanage, S Rayatpisheh… - Proceedings of the …, 2020 - National Acad Sciences
MicroRNAs (miRNAs) function cell-intrinsically to regulate gene expression by base-pairing
to complementary mRNA targets while in association with Argonaute, the effector protein of …

Next generation sequencing methods for diagnosis of epilepsy syndromes

P Dunn, CL Albury, N Maksemous, MC Benton… - Frontiers in …, 2018 - frontiersin.org
Epilepsy is a neurological disorder characterized by an increased predisposition for
seizures. Although this definition suggests that it is a single disorder, epilepsy encompasses …

MicroRNA expression levels are altered in the cerebrospinal fluid of patients with young-onset Alzheimer's disease

PM McKeever, R Schneider, F Taghdiri… - Molecular …, 2018 - Springer
Clinical diagnosis of Alzheimer's disease (AD) prior to the age of 65 years is classified as
young-onset (YOAD), whereas diagnosis after the age of 65 years is considered late-onset …

MicroRNA-21 is a versatile regulator and potential treatment target in central nervous system disorders

X Bai, Z Bian - Frontiers in molecular neuroscience, 2022 - frontiersin.org
MicroRNAs (miRNAs) are a class of endogenous, non-coding, single-stranded RNAs with a
length of approximately 22 nucleotides that are found in eukaryotes. miRNAs are involved in …

Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer's disease

A Kenny, EM Jimenez-Mateos, MA Zea-Sevilla… - Scientific reports, 2019 - nature.com
Alzheimer's disease (AD) is characterized by a progressive loss of neurons and cognitive
functions. Therefore, early diagnosis of AD is critical. The development of practical and non …

The role of Raman spectroscopy within quantitative metabolomics

C Lima, H Muhamadali… - Annual Review of …, 2021 - annualreviews.org
Ninety-four years have passed since the discovery of the Raman effect, and there are
currently more than 25 different types of Raman-based techniques. The past two decades …

Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy

R Raoof, S Bauer, H El Naggar, NMC Connolly… - …, 2018 - thelancet.com
Background There are no blood-based molecular biomarkers of temporal lobe epilepsy
(TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong …

Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions

VM Golub, DS Reddy, C France - Pharmacological reviews, 2022 - Elsevier
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …