Carbonic anhydrase activators
CT Supuran - Future medicinal chemistry, 2018 - Taylor & Francis
Mammalian carbonic anhydrases (CAs; EC 4.2. 1.1) of which 16 isoforms are known, are
involved in important physiological functions. Their inhibition is exploited pharmacologically …
involved in important physiological functions. Their inhibition is exploited pharmacologically …
Carbonic anhydrase activators for neurodegeneration: an overview
V Poggetti, S Salerno, E Baglini, E Barresi… - Molecules, 2022 - mdpi.com
Carbonic anhydrases (CAs) are a family of ubiquitous metal enzymes catalyzing the
reversible conversion of CO2 and H2O to HCO3− with the release of a proton. They play an …
reversible conversion of CO2 and H2O to HCO3− with the release of a proton. They play an …
Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase
Abstract Aldose reductase (ALR2), one of the metabolically important enzymes, catalyzes
the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to …
the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to …
[PDF][PDF] Synthesis and antioxidant activities of Schiff bases and their complexes: An updated review
Schiff bases are chemical compounds formed from the condensation reaction of aldehydes
or ketones with amines. These compounds are majorly used in industries and also have …
or ketones with amines. These compounds are majorly used in industries and also have …
New Ni (II) and Pd (II) complexes bearing derived sulfa drug ligands: synthesis, characterization, DFT calculations, and in silico and in vitro biological activity studies
MA Bourouai, K Si Larbi, A Bouchoucha… - Biometals, 2023 - Springer
In the present study, the synthesis of six new Ni (II) and Pd (II) complexes with three derived
sulfamethoxazole drug ligands is reported. The coordination mode, geometry, and chemical …
sulfamethoxazole drug ligands is reported. The coordination mode, geometry, and chemical …
Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors
Isocoumarins, isomeric to comarins which act as effective carbonic anhydrase (CA, EC 4.2.
1.1) inhibitors, were investigated for the first time as inhibitors of this enzyme. A series of 3 …
1.1) inhibitors, were investigated for the first time as inhibitors of this enzyme. A series of 3 …
Discovery of new ureido benzenesulfonamides incorporating 1, 3, 5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors
A series of twenty novel ureido benzenesulfonamides incorporating 1, 3, 5-triazine moieties
substituted on one side with aromatic amines and on the other side with dimethylamine …
substituted on one side with aromatic amines and on the other side with dimethylamine …
Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties
A novel series of twelve aromatic bis-ureido-substituted benzenesulfonamides was
synthesised by conjugation of aromatic aminobenzenesulfonamides with aromatic bis …
synthesised by conjugation of aromatic aminobenzenesulfonamides with aromatic bis …
Design and synthesis of novel 1, 3-diaryltriazene-substituted sulfonamides as potent and selective carbonic anhydrase II inhibitors
Abstract A series of novel 1, 3-diaryltriazene-substituted sulfonamides was synthesized by
reaction of diazonium salt of 4-amino benzenesulfonamide with substituted aromatic …
reaction of diazonium salt of 4-amino benzenesulfonamide with substituted aromatic …
Activation of α-, β-, γ-δ-, ζ-and η-class of carbonic anhydrases with amines and amino acids: A review
S Akocak, CT Supuran - Journal of enzyme inhibition and …, 2019 - Taylor & Francis
Eight genetically distinct carbonic anhydrase (EC 4.2. 1.1) enzyme families (α-, β-, γ-δ-, ζ-, η-
, θ-and ι-CAs) were described to date. On the other hand, 16 mammalian α-CA isoforms are …
, θ-and ι-CAs) were described to date. On the other hand, 16 mammalian α-CA isoforms are …