Non-coding RNA in hepatocellular carcinoma: mechanisms, biomarkers and therapeutic targets

M Klingenberg, A Matsuda, S Diederichs, T Patel - Journal of hepatology, 2017 - Elsevier
The majority of the human genome is not translated into proteins but can be transcribed into
RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins …

Long non-coding RNAs as biomarkers and therapeutic targets: recent insights into hepatocellular carcinoma

L Qiu, Q Tang, G Li, K Chen - Life sciences, 2017 - Elsevier
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer worldwide, and
the survival rates of patients with HCC remains quite low after 5 years. Long non-coding …

circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma

X Zhang, Y Xu, Z Qian, W Zheng, Q Wu, Y Chen… - Cell death & …, 2018 - nature.com
Some types of circular RNA (circRNA) are aberrantly expressed in human diseases
including hepatocellular carcinoma (HCC). However, its regulation mechanism and …

Serum small extracellular vesicle‐derived LINC00853 as a novel diagnostic marker for early hepatocellular carcinoma

SS Kim, GO Baek, HR Ahn, S Sung, CW Seo… - Molecular …, 2020 - Wiley Online Library
This study aimed to identify novel long noncoding RNA (lncRNA) biomarkers for
hepatocellular carcinoma (HCC) using publicly available tissue genomic datasets and …

Non-coding RNAs in hepatocellular carcinoma: Insights into regulatory mechanisms, clinical significance, and therapeutic potential

Q Han, M Wang, X Dong, F Wei, Y Luo… - Frontiers in …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is a complex and heterogeneous malignancy with high
incidence and poor prognosis. In addition, owing to the lack of diagnostic and prognostic …

The role of long non-coding RNAs in hepatocarcinogenesis

M Lanzafame, G Bianco, LM Terracciano… - International journal of …, 2018 - mdpi.com
Whole-transcriptome analyses have revealed that a large proportion of the human genome
is transcribed in non-protein-coding transcripts, designated as long non-coding RNAs …

A circulating long noncoding RNA panel serves as a diagnostic marker for hepatocellular carcinoma

J Huang, Y Zheng, X Xiao, C Liu, J Lin… - Disease …, 2020 - Wiley Online Library
Background. Circulating long noncoding RNAs (lncRNAs) have been demonstrated to serve
as diagnostic biomarkers for various cancers. We aimed to elucidate the diagnostic efficacy …

[HTML][HTML] The role of long non-coding RNA in hepatocellular carcinoma

W Liang, Y Zhao, Q Meng, W Jiang, S Deng… - Aging (Albany NY …, 2024 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is a prevalent liver malignancy with complex etiology and
generally poor prognosis. Recently, long non-coding RNAs (lncRNAs), non-protein-coding …

LncRNA HClnc1 facilitates hepatocellular carcinoma progression by regulating PKM2 signaling and indicates poor survival outcome after hepatectomy

Q Zhu, Z Lei, C Xu, Z Zhang, Z Yu, Z Cheng… - Cancer …, 2023 - Wiley Online Library
Abstract Aim Long noncoding RNAs (lncRNAs) are key mediators with a wide range of
pathophysiological functions, but their role in human hepatocellular carcinoma (HCC) is still …

Circulating long and circular noncoding RNA as non-invasive diagnostic tools of hepatocellular carcinoma

CHC Sukowati, LKD Cabral, C Tiribelli, D Pascut - Biomedicines, 2021 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death
worldwide, partially due to late diagnosis of the disease. Growing evidence in the field of …