ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors
Background ATM is a multifunctional serine/threonine kinase that in addition to its well-
established role in DNA repair mechanisms is involved in a number of signaling pathways …
established role in DNA repair mechanisms is involved in a number of signaling pathways …
Andrographolide suppresses aerobic glycolysis and induces apoptotic cell death by inhibiting pyruvate dehydrogenase kinase 1 expression
ES Yang, Y Do, SY Cheon, B Kim… - Oncology …, 2023 - spandidos-publications.com
Metabolic disorder is a major characteristic of cancer cells, and controlling genes involved in
metabolic shifts can be an effective strategy for cancer treatment. Andrographolide (AG), a …
metabolic shifts can be an effective strategy for cancer treatment. Andrographolide (AG), a …
Exosome-like Systems: From Therapies to Vaccination for Cancer Treatment and Prevention—Exploring the State of the Art
HH Sheikhhossein, F Iommelli, N Di Pietro, MC Curia… - Vaccines, 2024 - mdpi.com
Cancer remains one of the main causes of death in the world due to its increasing incidence
and treatment difficulties. Although significant progress has been made in this field …
and treatment difficulties. Although significant progress has been made in this field …
ITGB1 and DDR activation as novel mediators in acquired resistance to osimertinib and MEK inhibitors in EGFR-mutant NSCLC
Osimertinib is a third-generation tyrosine kinase inhibitor clinically approved for first-line
treatment of EGFR-mutant non-small cell lung cancer (NSCLC) patients. Although an …
treatment of EGFR-mutant non-small cell lung cancer (NSCLC) patients. Although an …
[HTML][HTML] Regulatory role of PDK1 via integrated gene analysis of mitochondria-immune response in periodontitis
X Sun, T Wu, Z Yang, S Chen, Z Zhao, C Hu, S Wu… - Gene, 2024 - Elsevier
Aims To investigate the association between mitochondrial events and immune response in
periodontitis and related regulatory genes. Main methods Gene expression profiles in …
periodontitis and related regulatory genes. Main methods Gene expression profiles in …
[PDF][PDF] MODULATION OF GLUCOSE METABOLISM IN ONCOGENE-DRIVEN TUMORS: IMPLICATIONS FOR THERAPY
C Terlizzi - fedoa.unina.it
Background and rationale: Activation of oncogenes or loss of function of suppressor genes,
in addition to induce neoplastic transformation, leads to a reprogramming of glucose …
in addition to induce neoplastic transformation, leads to a reprogramming of glucose …