Aminoglycoside antibiotics have had a major impact on our ability to treat bacterial infections
for the past half century. Whereas the interest in these versatile antibiotics continues to be …

The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

The key role of the bacterial ribosome makes it an important target for antibacterial agents.
Indeed, a large number of clinically useful antibiotics target this complex translational …

Herein is described the identification of RNA internal loops that bind to derivatives of
neomycin B, neamine, tobramycin, and kanamycin A. RNA loop− ligand partners were …

The ability of aminoglycoside antibiotics to promote read-through of nonsense mutations has
attracted interest in these drugs as potential therapeutic agents in genetic diseases …

Herein, we report the development of a microarray platform to select RNA motif− ligand
interactions that allows simultaneous screening of both RNA and chemical space. We used …

Myotonic muscular dystrophy types 1 and 2 (DM1 and DM2, respectively) are caused by
expansions of repeating nucleotides in noncoding regions of RNA. In DM1, the expansion is …

RNA is increasingly recognized for its significant functions in biological systems and has
recently become an important molecular target for therapeutics development …

The ribosome and its RNA components are targets for a diverse set of antibiotics, including
the natural aminoglycosides, macrolides, and tetracyclins and the synthetic oxazolidinones …

This book contains chapters highlighting the capabilities of pathogenic bacterial enzymes to
introduce chemical modifications that negate the antibacterial activities of β-lactam and …