Structural and functional complexity of HSP90 in cellular homeostasis and disease
Abstract Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating
proteostasis, long recognized for its function in protein folding and maturation. A view is …
proteostasis, long recognized for its function in protein folding and maturation. A view is …
The FKBP51 glucocorticoid receptor co-chaperone: regulation, function, and implications in health and disease
Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention
FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its
members have fundamental roles in the regulation of signalling pathways involved in …
members have fundamental roles in the regulation of signalling pathways involved in …
Biological actions of the Hsp90-binding immunophilins FKBP51 and FKBP52
NR Zgajnar, SA De Leo, CM Lotufo, AG Erlejman… - Biomolecules, 2019 - mdpi.com
Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-
isomerase domain. High molecular weight immunophilins are characterized by the …
isomerase domain. High molecular weight immunophilins are characterized by the …
Epigenetics as a key link between psychosocial stress and aging: concepts, evidence, mechanisms
AS Zannas - Dialogues in clinical neuroscience, 2019 - Taylor & Francis
Psychosocial stress—especially when chronic, excessive, or occurring early in life—has
been associated with accelerated aging and increased disease risk. With rapid aging of the …
been associated with accelerated aging and increased disease risk. With rapid aging of the …
Heat shock protein 90 as therapeutic target for CVDs and heart ageing
SA Dabravolski, VN Sukhorukov, VA Kalmykov… - International Journal of …, 2022 - mdpi.com
Cardiovascular diseases (CVDs) are the leading cause of death globally, representing
approximately 32% of all deaths worldwide. Molecular chaperones are involved in heart …
approximately 32% of all deaths worldwide. Molecular chaperones are involved in heart …
Heat shock protein 90: biological functions, diseases, and therapeutic targets
H Wei, Y Zhang, Y Jia, X Chen, T Niu, A Chatterjee… - MedComm, 2024 - Wiley Online Library
Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock
proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in …
proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in …
Proof that the high molecular weight immunophilin FKBP52 mediates the in vivo neuroregenerative effect of the macrolide FK506
C Daneri-Becerra, MG Patiño-Gaillez… - Biochemical …, 2020 - Elsevier
The immunosuppressant drug FK506 (or tacrolimus) is a macrolide that binds selectively to
immunophilins belonging to the FK506-binding protein (FKBP) subfamily, which are …
immunophilins belonging to the FK506-binding protein (FKBP) subfamily, which are …
Mitochondrial–nuclear communication by FKBP51 shuttling
The HSP90‐binding immunophilin FKBP51 is a soluble protein that shows high homology
and structural similarity with FKBP52. Both immunophilins are functionally divergent and …
and structural similarity with FKBP52. Both immunophilins are functionally divergent and …
The connection between cell fate and telomere
Abolition of telomerase activity results in telomere shortening, a process that eventually
destabilizes the ends of chromosomes, leading to genomic instability and cell growth arrest …
destabilizes the ends of chromosomes, leading to genomic instability and cell growth arrest …