Wound healing, fibroblast heterogeneity, and fibrosis
Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …
However, the mechanisms by which they contribute to both physiologic and pathologic …
Mechanical regulation of chromatin and transcription
S Dupont, SA Wickström - Nature Reviews Genetics, 2022 - nature.com
Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …
Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing
Abstract 'Smart'bandages based on multimodal wearable devices could enable real-time
physiological monitoring and active intervention to promote healing of chronic wounds …
physiological monitoring and active intervention to promote healing of chronic wounds …
A strain-programmed patch for the healing of diabetic wounds
Diabetic foot ulcers and other chronic wounds with impaired healing can be treated with
bioengineered skin or with growth factors. However, most patients do not benefit from these …
bioengineered skin or with growth factors. However, most patients do not benefit from these …
The role of myofibroblasts in physiological and pathological tissue repair
Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …
Cellular and molecular mechanisms of skin wound healing
Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …
[HTML][HTML] Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer
Adult mammalian skin wounds heal by forming fibrotic scars. We report that full-thickness
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar …
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar …
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting
Burns and other traumatic injuries represent a substantial biomedical burden. The current
standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which …
standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which …
Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells
Small animals do not replicate the severity of the human foreign-body response (FBR) to
implants. Here we show that the FBR can be driven by forces generated at the implant …
implants. Here we show that the FBR can be driven by forces generated at the implant …
Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings
Biological scaffolds such as hydrogels provide an ideal, physio‐mimetic of native
extracellular matrix (ECM) that can improve wound healing outcomes after cutaneous injury …
extracellular matrix (ECM) that can improve wound healing outcomes after cutaneous injury …