The ubiquitin-proteasome pathway is involved in intracellular protein turnover, and its
function is crucial to cellular homeostasis. First synthesized as probes of proteolytic …

Nuclear factor-κB (NF-κB) is a signal transcription factor that has emerged as an important
modulator of altered gene programs and malignant phenotype in development of cancer …

Purpose: Curcumin, a component of turmeric, has been shown to suppress inflammation
and angiogenesis largely by inhibiting the transcription factor nuclear factor-κB (NF-κB). This …

Proteasome inhibitors sensitize tumor cells to DNA-damaging agents, including ionizing
radiation (IR), and DNA cross-linking agents (melphalan and cisplatin) through unknown …

Although most ovarian cancer patients are highly responsive to chemotherapy, they
frequently present with recurrent metastatic lesions that result in poor overall survival, a …

BACKGROUND: Recent work has suggested a role for nuclear factor κB (NF‐κB) in the
propagation of ovarian cancer cell lines, but the significance and mechanism of NF‐κB in …

The NF-κB signaling pathway is a complex network linking extracellular stimuli to cell
survival and proliferation. Cytoplasmic signaling to activate NF-κB can occur as part of the …

The roles of HOX transcription factors as oncogenes and tumor suppressor genes, and the
NF-KB pathway in chronic inflammation, both leading to cancer are well-established. HOX …

A major challenge in cancer therapy is tumor drug resistance. To overcome it, it is essential
to understand the mechanisms and identify the molecules involved, so that they can be …

Nuclear transcription factor κB (NF-κB) was first discovered in 1986 in the nucleus of the B
cell as an enhancer in the κ immunoglobulin chain. However, this factor has identified in the …