Research conducted in the past 15 years has yielded crucial insights that are reshaping our
understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism …

The essential amino acid tryptophan (Trp) is metabolized by gut commensals, yielding in
compounds that affect innate immune cell functions directly, but also acting on the aryl …

Obesity, dyslipidemia and gut dysbiosis are all linked to cardiovascular diseases. A
Ganoderma meroterpene derivative (GMD) has been shown to alleviate obesity and …

As important metabolic substrates, branched-chain amino acids (BCAAs) and fatty acids
(FAs) participate in many significant physiological processes, such as mitochondrial …

Lifespan and metabolic health are influenced by dietary nutrients. Recent studies show that
a reduced protein intake or low-protein/high-carbohydrate diet plays a critical role in …

High-throughput metabolite profiling provides the opportunity to reveal metabolic
mechanisms and identify biomarkers. Psoriasis is an immune-mediated chronic …

The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are important
nitrogen donors for synthesis of glutamate, the main excitatory neurotransmitter in the brain …

Background Circulating levels of amino acids were associated with blood pressure (BP) in
observational studies. However, the causation of such associations has been hypothesized …

Cardiovascular disease (CVD) is one of the major causes of mortality worldwide.
Inflammation is the underlying common mechanism involved in CVD. It has been recently …

Background Epidemiological studies demonstrated that multiple amino acids (AAs) were
associated with cardiovascular diseases (CVDs), but whether these associations were …