Microglia: Immune and non-immune functions

K Borst, AA Dumas, M Prinz - Immunity, 2021 - cell.com
As resident macrophages of the central nervous system (CNS), microglia are associated
with diverse functions essential to the developing and adult brain during homeostasis and …

Pathogenesis underlying neurological manifestations of long COVID syndrome and potential therapeutics

A Leng, M Shah, SA Ahmad, L Premraj, K Wildi… - Cells, 2023 - mdpi.com
The development of long-term symptoms of coronavirus disease 2019 (COVID-19) more
than four weeks after primary infection, termed “long COVID” or post-acute sequela of …

cGAS–STING drives ageing-related inflammation and neurodegeneration

MF Gulen, N Samson, A Keller, M Schwabenland… - Nature, 2023 - nature.com
Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …

Neurovascular injury with complement activation and inflammation in COVID-19

MH Lee, DP Perl, J Steiner, N Pasternack, W Li… - Brain, 2022 - academic.oup.com
The underlying mechanisms by which severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) leads to acute and long-term neurological manifestations remains obscure …

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

C Greene, R Connolly, D Brennan, A Laffan… - Nature …, 2024 - nature.com
Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19)
pathogenesis and may predispose to the neurological sequelae associated with long …

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

A Bertoletti, N Le Bert, AT Tan - Immunity, 2022 - cell.com
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …

Integrating spatial and single-nucleus transcriptomic data elucidates microglial-specific responses in female cynomolgus macaques with depressive-like behaviors

J Wu, Y Li, Y Huang, L Liu, H Zhang, C Nagy… - Nature …, 2023 - nature.com
Major depressive disorder represents a serious public health challenge worldwide;
however, the underlying cellular and molecular mechanisms are mostly unknown. Here, we …

The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2

S Krasemann, U Haferkamp, S Pfefferle, MS Woo… - Stem cell reports, 2022 - cell.com
Neurological complications are common in COVID-19. Although SARS-CoV-2 has been
detected in patients' brain tissues, its entry routes and resulting consequences are not well …

Acute and chronic neurological disorders in COVID-19: potential mechanisms of disease

EF Balcom, A Nath, C Power - Brain, 2021 - academic.oup.com
Abstract Coronavirus disease 2019 (COVID-19) is a global pandemic caused by SARS-CoV-
2 infection and is associated with both acute and chronic disorders affecting the nervous …