Hepatocellular carcinoma (HCC) has been linked to the gut microbiota, with recent studies
revealing the potential of gut-generated responses to influence several arms of the immune …

Background: Liver cancer, particularly hepatocellular carcinoma (HCC), is a significant
gastrointestinal disease with a mortality rate as high as nearly 80% within five years. The …

Background & Aims Hepatocellular carcinoma (HCC) is a male-dominant disease, but
targeted sex hormone therapies have not been successful. Bile acids are a potential liver …

Bile acids (BAs) play important roles in the digestion of dietary fats and molecular signal
transduction, and modulation of the BA composition usually affects the progression of …

Sporadic occurrence of congenital portosystemic shunt (PSS) at a rate of∼ 1 out of 10
among C57BL/6 J mice, which are widely used in biomedical research, results in …

Excessive alcohol consumption is a major global health problem. Individuals with alcoholic
liver disease often exhibit elevated serum total bile acids (TBAs). Nevertheless, the extent to …

A significant fraction of the popular inbred C57Bl/6J mice show structural and biochemical
features of the congenital portosystemic shunt (PSS). How this hepatic abnormality affects …

Hepatocellular carcinoma (HCC) is the third cause of cancer-related mortality worldwide.
Current treatments include surgery and immunotherapy with variable response. Despite …

Although the liver is the largest metabolic organ in the body, it is not alone in functionality
and is assisted by “an organ inside an organ,” the gut microbiota. This review attempts to …

Immunologic and metabolic signals regulated by gut microbiota and relevant metabolites
mediate bidirectional interaction between the gut and liver. Gut microbiota dysbiosis, due to …