The therapeutic potential of triptolide and celastrol in neurological diseases

Y Cui, X Jiang, J Feng - Frontiers in Pharmacology, 2022 - frontiersin.org
Neurological diseases are complex diseases affecting the brain and spinal cord, with
numerous etiologies and pathogenesis not yet fully elucidated. Tripterygium wilfordii Hook …

[HTML][HTML] Progress in traditional Chinese medicine and natural extracts for the treatment of lupus nephritis

YJ Wang, YX Li, S Li, W He, ZR Wang, TP Zhan… - Biomedicine & …, 2022 - Elsevier
Lupus nephritis (LN) is an autoimmune disease with multiple system involvement and is also
one of the most serious forms of organ damage in systemic lupus erythematosus (SLE) …

Glycyrrhizic acid-lipid framework nanovehicle loading triptolide for combined immunochemotherapy

Z Xu, Y Huang, Y Wu, J Chen, SW Seto… - … Applied Materials & …, 2023 - ACS Publications
Despite the acknowledged advantages of combined immunochemotherapy for tumor
treatment, the high efficiency of co-delivery of these combined agents into the targeted tumor …

Chlorogenic acid, rutin, and quercetin from Lysimachia christinae alleviate triptolide-induced multi-organ injury in vivo by modulating immunity and AKT/mTOR signal …

X Wu, J Wang, B Li, M Gong, C Cao, L Song… - Toxicology and Applied …, 2023 - Elsevier
Drug-induced organ injury is one of the key factors causing organ failure and death in the
global public. Triptolide (TP) is the main immunosuppressive component of Tripterygium …

[HTML][HTML] A single-cell landscape of triptolide-associated testicular toxicity in mice

W Zhang, S Xia, J Ou, M Cao, G Cheng, Z Li… - Journal of …, 2023 - Elsevier
Triptolide is a key active component of the widely used traditional Chinese herb medicine
Tripterygium wilfordii Hook. F. Although triptolide exerts multiple biological activities and …

Insights into the mechanisms of triptolide nephrotoxicity through network pharmacology-based analysis and RNA-seq

YM Luo, SD Yang, MY Wen, B Wang, JH Liu… - Frontiers in Plant …, 2023 - frontiersin.org
Introduction Triptolide (TPL) is a promising plant-derived compound for clinical therapy of
multiple human diseases; however, its application was limited considering its toxicity …

[HTML][HTML] New mechanism of nephrotoxicity of triptolide: Oxidative stress promotes cGAS-STING signaling pathway

J Lu, Y Zhang, H Dong, J Sun, L Zhu, P Liu… - Free Radical Biology …, 2022 - Elsevier
Triptolide (TPL) is a bioactive component extracted from the traditional Chinese herb
Tripterygium wilfordii Hook F., and has multiple pharmacological activities, such as anti …

Natural-product-derived adjunctive treatments to conventional therapy and their immunoregulatory activities in triple-negative breast cancer

LLY Kan, BCL Chan, PC Leung, CK Wong - Molecules, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is an invasive and persistent subtype of breast cancer
that is likely to be resistant to conventional treatments. The rise in immunotherapy has …

A comprehensive review of Tripterygium wilfordii hook. f. in the treatment of rheumatic and autoimmune diseases: Bioactive compounds, mechanisms of action, and …

Y Shan, J Zhao, K Wei, P Jiang, L Xu… - Frontiers in …, 2023 - frontiersin.org
Rheumatic and autoimmune diseases are a group of immune system-related disorders
wherein the immune system mistakenly attacks and damages the body's tissues and organs …

Idiopathic pulmonary fibrosis Molecular substrates revealed by competing endogenous RNA Regulatory Networks

MF Kircali, B Turanli - OMICS: A Journal of Integrative Biology, 2023 - liebertpub.com
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic disease of the lung with
poor prognosis. Fibrosis results from remodeling of the interstitial tissue. A wide range of …