Schwann cells within the peripheral nervous system possess a remarkable regenerative
potential. Current research shows that peripheral nerve‐associated Schwann cells possess …

The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-
related kinase receptor type B (TRKB) are actively produced and trafficked in multiple …

Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote
distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph …

▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

The vertebrate transcription factor NF-κB is induced by over 150 different stimuli. Active NF-
κB, in turn, participates in the control of transcription of over 150 target genes. Because a …

Neurotrophins use two types of receptors, the Trk tyrosine kinase receptors and the p75
neurotrophin receptor (p75NTR), to regulate the growth, development, survival and repair of …

Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in
thedeveloping and adult mammalian brain. BDNF/TrkB-stimulated intracellular signaling is …

▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

Neurons are specialized cells with a complex morphology that represent the functional unit
of the nervous system. They are generated in remarkable numbers, particularly in higher …

Transcription factors provide the link between early membrane-proximal signalling events
and changes in gene expression. NF-kB is one of the best-characterized transcription …