The actin cytoskeleton is the primary driver of cellular adhesion and mechanosensing due to
its ability to generate force and sense the stiffness of the environment. At the cell's leading …

The effects of N-terminal acetylation of the high molecular weight tropomyosin isoforms
Tpm1. 6 and Tpm2. 1 and the low molecular weight isoforms Tpm1. 12, Tpm3. 1, and Tpm4 …

Proteins of the ADF/cofilin family play a central role in the disassembly of actin filaments, and
their activity must be tightly regulated in cells. Recently, the oxidation of actin filaments by …

Biomolecular complexes can form stable assemblies yet can also rapidly exchange their
subunits to adapt to environmental changes. Simultaneously allowing for both stability and …

As the major channel of aqueous humor outflow, dysfunction of trabecular meshwork (TM)
can lead to intraocular pressure elevating, which can trigger primary open-angle glaucoma …

The precise assembly and disassembly of actin filaments is required for several cellular
processes, and their regulation has been scrutinized for decades. Twenty years ago, a …

Force generation and motility by actomyosin in nonmuscle cells are spatially regulated by∼
40 tropomyosin (Tpm) isoforms. The means by which Tpms are targeted to specific cellular …

The actin cytoskeleton is one of the most important players in cell motility, adhesion, division,
and functioning. The regulation of specific microfilament formation largely determines …

The actin cytoskeleton is composed of both branched and unbranched actin filaments. In
mammals, the unbranched actin filaments are primarily copolymers of actin and …

With the increasing demand for imaging quality, many scientists constantly explore new
imaging instruments to meet the requirements. The total internal reflection fluorescence …