Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that
regulates various biological processes, including proliferation, metastasis, angiogenesis …

Transcription factors are proteins able to bind DNA and induce the transcription of specific
genes. Consequently, they play a pivotal role in multiple cellular pathways and are …

Allosteric modulators bound to structurally diverse allosteric sites can achieve better
pharmacological advantages than orthosteric ligands. The discovery of allosteric …

Signal transducer and activator of transcription 3 (STAT3) plays a critical role in signal
transmission from the plasma membrane to the nucleus, regulating the expression of genes …

As a transcription factor, STAT3 protein transduces extracellular signals to the nucleus and
then activates transcription of target genes. STAT3 has been well validated as an attractive …

Nowadays, simultaneous inhibition of multiple targets through drug combination is an
important anticancer strategy owing to the complex mechanism behind tumorigenesis …

Background The effects of some drugs, aging, cancers, and other diseases can cause
muscle wasting. Currently, there are no effective drugs for treating muscle wasting. In this …

A core concept behind modern drug discovery is finding a small molecule that modulates a
function of a target protein. This concept has been successfully applied since the mid-1970s …

Napabucasin (6) and its angularly anellated isomer (7), for which the synthesis is described,
together with related plant-derived naphthoquinones, were evaluated in vitro against human …

Signal transducer and activator of transcription 3 (STAT3) is an attractive target for cancer
therapy. However, identifying potent and selective STAT3 small-molecule inhibitors with …