Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

The importance of cancer-cell-autonomous functions of the tumour suppressor p53
(encoded by TP53) has been established in many studies, but it is now clear that the p53 …

Inducing antigen-specific tolerance during an established immune response typically
requires non-specific immunosuppressive signalling molecules. Hence, standard treatments …

As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded
by TP 53) plays a central role in response to various cellular stresses. A variety of biological …

p53 is a transcription factor that regulates the expression of genes involved in tumor
suppression. p53 mutations mediate tumorigenesis and occur in approximately 50% of …

Targeting the p53–MDM2 pathway to reactivate tumor p53 is a chemotherapeutic approach.
However, the involvement of this pathway in CD8+ T cell-mediated antitumor immunity is …

Subsets of human tumors are infiltrated with tumor antigen–specific CD8+ T cells [tumor-
infiltrating lymphocytes (TILs)] despite tumor progression. These TILs are thought to be …

Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer
malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to …

Awareness of the importance of immunity in controlling cancer development triggered
research into the impact of its key oncogenic drivers on the immune response, as well as …

Chimeric antigen receptor (CAR) T cells and natural killer (NK) cells are genetically
engineered immune cells that can detect target antigens on the surface of target cells and …