Restoring lost cognitive function

TW Berger, A Ahuja, SH Courellis… - IEEE engineering in …, 2005 - ieeexplore.ieee.org
A prosthetic device that functions in a biomimetic manner to replace information
transmission between cortical brain regions is considered. In such a prosthesis, damaged …

An integrated approach to classifying neuronal phenotypes

M Migliore, GM Shepherd - Nature Reviews Neuroscience, 2005 - nature.com
Characterizing the functional phenotypes of neurons is essential for understanding how
genotypes can be related to the neural basis of behaviour. Traditional classifications of …

Morpho-functional characterization of neuronal cells at different stages of maturation in granule cell layer of adult rat dentate gyrus

P Ambrogini, D Lattanzi, S Ciuffoli, D Agostini, L Bertini… - Brain research, 2004 - Elsevier
Neurogenesis occurs throughout adult life in dentate gyrus of mammal hippocampus.
Therefore, neurons at different stages of electrophysiological and morphological maturation …

Nonlinear dynamic modeling of spike train transformations for hippocampal-cortical prostheses

D Song, RHM Chan, VZ Marmarelis… - IEEE Transactions …, 2007 - ieeexplore.ieee.org
One of the fundamental principles of cortical brain regions, including the hippocampus, is
that information is represented in the ensemble firing of populations of neurons, ie, spatio …

Nonlinear modeling of neural population dynamics for hippocampal prostheses

D Song, RHM Chan, VZ Marmarelis, RE Hampson… - Neural Networks, 2009 - Elsevier
Developing a neural prosthesis for the damaged hippocampus requires restoring the
transformation of population neural activities performed by the hippocampal circuitry. To …

Abnormal excitability of oblique dendrites implicated in early Alzheimer's: a computational study

T Morse, NT Carnevale, P Mutalik, M Migliore… - Frontiers in neural …, 2010 - frontiersin.org
The integrative properties of cortical pyramidal dendrites are essential to the neural basis of
cognitive function, but the impact of amyloid beta protein (aβ) on these properties in early …

Ionotropic Glutamate Receptors and Voltage‐Gated Ca2+ Channels in Long‐Term Potentiation of Spinal Dorsal Horn Synapses and Pain Hypersensitivity

D Youn, G Gerber, WA Sather - Neural plasticity, 2013 - Wiley Online Library
Over the last twenty years of research on cellular mechanisms of pain hypersensitivity, long‐
term potentiation (LTP) of synaptic transmission in the spinal cord dorsal horn (DH) has …

Modulation of Cav3.2 T‐type Ca2+ channels by protein kinase C

JY Park, SW Jeong, E Perez-Reyes, JH Lee - FEBS letters, 2003 - Wiley Online Library
Although T‐type Ca2+ channels have been implicated in numerous physiological functions,
their regulations by protein kinases have been obscured by conflicting reports. We …

Down-regulation of delayed rectifier K+ channels in the hippocampus of seizure sensitive gerbils

SM Lee, JE Kim, JH Sohn, HC Choi, JS Lee… - Brain research …, 2009 - Elsevier
In order to confirm the species-specific distribution of voltage-gated K+ (Kv) channels and
the definitive relationship between their immunoreactivities and seizure activity, we …

Amyloid β‐protein fragment 31–35 suppresses delayed rectifying potassium channels in membrane patches excised from hippocampal neurons in rats

JS Qi, L Ye, JT Qiao - Synapse, 2004 - Wiley Online Library
To clarify the early initial mechanism underlying the neurotoxicity of amyloid β‐protein (AβP)
and the shorter essential active sequence in native AβP molecules, the effects of AβP31–35 …