Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Matrix metalloproteinases have long been associated with cancer. Clinical trials of small
molecule inhibitors for this family of enzymes however, were spectacularly unsuccessful in a …

Matrix metalloproteinases (MMPs) are now acknowledged as key players in the regulation of
both cell–cell and cell–extracellular matrix interactions. They are involved in modifying …

Novel molecular imaging techniques have the potential to significantly enhance the
diagnostic and therapeutic approaches for cancer treatment. For solid tumors in particular …

High-resolution imaging of molecules intrinsically involved in malignancy and metastasis
would be of great value for clinical detection and staging of tumors. We now report in vivo …

Molecular imaging has emerged at the end of the last century as an interdisciplinary method
involving in vivo imaging and molecular biology aiming at identifying living biological …

This review focuses on MRI contrast agents that are responsive to a change in a
physiological biomarker. The response mechanisms are dependent on six physicochemical …

Imaging of enzyme activity in living subjects promises many applications in both basic and
translational researches from helping elucidate the enzyme function and mechanism in …

Activatable cell penetrating peptides (ACPPs) are novel in vivo targeting agents comprised
of a polycationic cell penetrating peptide (CPP) connected via a cleavable linker to a …

We report here a protease sensing nanoplatform based on semiconductor nanocrystals or
quantum dots (QDs) and bioluminescence resonance energy transfer (QD-BRET) to detect …