Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …

Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …

Triple negative breast cancer (TNBC) is most aggressive subtype of breast cancers with high
probability of metastasis as well as lack of specific targets and targeted therapeutics. TNBC …

Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell
activation pathways involved in physiological immune responses against specific antigens …

Immune checkpoint blockade has shown unprecedented and durable clinical response in a
wide range of cancers. T cell immunoglobulin and mucin domain 3 (TIM3) is an inhibitory …

Polyphenols are potent micronutrients that can be found in large quantities in various food
sources and spices. These compounds, also known as phenolics due to their phenolic …

Immunotherapy strategies targeting the programmed cell death ligand 1 (PD-
L1)/programmed cell death 1 (PD-1) pathway in clinical treatments have achieved …

Breast cancer was traditionally not considered a particularly immunogenic tumor. However,
recent developments have shown that some aggressive triple-negative breast cancers are …

A balance between co-inhibitory and co-stimulatory signals in the tumor microenvironment
(TME) is critical to suppress tumor development and progression, primarily via maintaining …