Design and evaluation of losartan potassium effervescent floating matrix tablets: In vivo x-ray imaging and pharmacokinetic studies in Albino Rabbits

M Rahamathulla, S Saisivam, A Alshetaili, U Hani… - Polymers, 2021 - mdpi.com
Losartan potassium (LP) is an angiotensin receptor blocker used to treat hypertension. At
higher pH, it shows poor aqueous solubility, which leads to poor bioavailability and lowers …

Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intra-ocular pressure in normotensive rabbit: Sustained structural relaxation …

S Nandi, R Swain, S Habibullah… - Pharmaceutical …, 2024 - Taylor & Francis
Carboxylesterase enzymes convert a prodrug ramipril into the biologically active metabolite
ramiprilat. It is prescribed for controlling ocular hypertension after oral administration. High …

Formulation and administration of ramipril prodrug for improving bioactivity significantly: In vitro and in vivo correlation

S Nandi, A Nanda, RN Sahoo, R Swain… - Journal of Drug Delivery …, 2022 - Elsevier
Ramipril (RAM), a prodrug is converted to the active metabolite, ramiprilat (RAT) after de-
esterification in the liver for pharmacologic activity. RAM is advisable for the control of ocular …

pH-dependent pulsatile delivery of Ambrisentan for the treatment of hypertension.

A KANUGO, R DHAGE - Journal of Research in Pharmacy, 2023 - search.ebscohost.com
The greatest number of mortality in the world occurred due to hypertension. Several bodily
functions are based on circadian rhythm including hypertension. The stimulation of the …

Antihypertensives' Rock around the Clock

Although homeostasis is a commonly accepted concept, there is incontrovertible evidence
that biological processes and functions are variable and that variability occurs in cycles. In …

[PDF][PDF] PULSATILE DRUG DELIVERY SYSTEMS THE NOVEL APPROACH

V BODKE, BW TEKADE, R BADEKAR, SD PHALAK… - 2024 - academia.edu
Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag
phases before a quick and quantifiable, repeated, or prolonged medication release. As a …

Obtenção e caracterização de Co-amorfos do anti-hipertensivo Ramipril com o ácido oxálico

YMM LIMA - 2022 - tede2.ufma.br
Os fármacos são materiais obtidos com a finalidade medicamentosa de prevenir, curar
doenças ou aliviar seus sintomas. A obtenção de dispersões sólidas de fármacos (DSFs) …

Antihypertensives' Rock around the Clock

A Tucak, M Sirbubalo, L Hindija, J Hadžiabdić - J, 2021 - search.proquest.com
Although homeostasis is a commonly accepted concept, there is incontrovertible evidence
that biological processes and functions are variable and that variability occurs in cycles. In …

[PDF][PDF] Fabrication and evaluation of Lercanidipine hydrochloride solid dispersions to improve its solubility and stability

ML Thadanki, M Ramaiah, SS Devu - iscientific.org
Most commonly, hypertension and angina pectoris are treated with lercanidipine, a
vasoselective dihydropyridine calcium antagonist. Nevertheless, lercanidipine main …

[PDF][PDF] OBTENÇÃO E CARACTERIZAÇÃO DE UM NOVO CO-AMORFO DO ANTI-HIPERTENSIVO RAMIPRIL OBTAINING AND CHARACTERIZING A NEW CO …

YMM Lima, PRS Ribeiro, LHS Queiroz, R DS - CEP - researchgate.net
Drugs are materials designed to prevent, cure diseases or alleviate their symptoms. They
are defined as the active ingredient in medicines. Most of them have low water solubility …