Anticancer steroids: linking natural and semi-synthetic compounds

JAR Salvador, JFS Carvalho, MAC Neves… - Natural product …, 2013 - pubs.rsc.org
Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

Man-made cytotoxic steroids: exemplary agents for cancer therapy

R Bansal, PC Acharya - Chemical reviews, 2014 - ACS Publications
Cancer is one of the most dreaded diseases to haunt mankind in the world today. It is one of
the leading causes of death worldwide. Although overall cancer incidence rates in the …

[图书][B] Progress in the chemistry of organic natural products

AD Kinghorn, H Falk, S Gibbons, Y Asakawa, JK Liu… - 2021 - Springer
Termites (Isoptera), which are a suborder of the cockroaches, are the oldest eusocial insects
[1–3]. It is assumed that they diverged from the Cryptocercoidae, woodfeeding cockroaches …

Recent progress of novel steroid derivatives and their potential biological properties

S Ke - Mini reviews in medicinal chemistry, 2018 - ingentaconnect.com
Steroid and its derivatives have been proved to have important and diverse biological
functions, which present the wide spectrum of biological activities such as antitumor …

Recent advances in design, synthesis and bioactivity of paclitaxel-mimics

G Wen, XX Qu, D Wang, XX Chen, XC Tian, F Gao… - Fitoterapia, 2016 - Elsevier
Taxane-type anticancer drugs, including paclitaxel and its semi-synthetic derivatives
docetaxel and cabazitaxel, are widely applied to chemotherapy of malignancy like breast …

Induction of a non-apoptotic mode of cell death associated with autophagic characteristics with steroidal maleic anhydrides and 7β-hydroxycholesterol on glioma cells

K Sassi, T Nury, A Zarrouk, R Sghaier… - The Journal of steroid …, 2019 - Elsevier
Steroidal maleic anhydrides were prepared in one step: lithocholic, chenodeoxicholic,
deoxicholic, ursocholic, and hyodeoxicholic acid derivatives. Their capability to induce cell …

Antiparasitic hybrids of Cinchona alkaloids and bile acids

A Leverrier, J Bero, M Frédérich… - European Journal of …, 2013 - Elsevier
A series of 16 hybrids of Cinchona alkaloids and bile acids (4a–h, 5a–h) was prepared by
means of a Barton–Zard decarboxylation reaction. Quinine, quinidine, cinchonine and …

Direct C–H alkylation of naphthoquinones with amino acids through a revisited Kochi–Anderson radical decarboxylation: Trends in reactivity and applications

G Naturale, M Lamblin, C Commandeur… - European Journal of …, 2012 - Wiley Online Library
In our ongoing research program into the discovery of new anticancer drugs, we were
interested in the preparation of naphthoquinone scaffolds bearing aminoalkyl side‐chains …

A Critical Evaluation of the Quality of Published 13C NMR Data in Natural Product Chemistry

W Robien - Progress in the Chemistry of Organic Natural Products …, 2017 - Springer
Abstract Nuclear Magnetic Resonance spectroscopy contributes very efficiently to the
structure elucidation process in organic chemistry. Carbon-13 NMR spectroscopy allows …

Structure-activity relationship of hybrids of Cinchona alkaloids and bile acids with in vitro antiplasmodial and antitrypanosomal activities

A Leverrier, J Bero, J Cabrera, M Frédérich… - European Journal of …, 2015 - Elsevier
In this work, a series of hybrid compounds were tested as antiparasitic substances. These
hybrids were prepared from bile acids and a series of antiparasitic Cinchona alkaloids by …