Recent studies show an important role for non-neutralizing anti-spike antibodies, including
monoclonal antibodies (mAbs), in robustly protecting against SARS-CoV-2 infection. These …

Historically, antibodies have been divided into two functionally independent domains, the
variable (V) region for antigen binding and the constant (C) region for mediating effector …

Although young children generally experience mild symptoms following infection with SARS-
CoV-2, severe acute and long-term complications can occur. SARS-CoV-2 mRNA vaccines …

Streptococcus pyogenes can cause invasive disease with high mortality despite adequate
antibiotic treatments. To address this unmet need, we have previously generated an opsonic …

Vaccination with the primary two-dose series of SARS-CoV-2 mRNA protects against
infection with the ancestral strain, and limits the presentation of severe disease after re …

Despite the unique advantages of IgG3 over other IgG subclasses, such as mediating
enhanced effector functions and increased flexibility in antigen binding due to a long hinge …

Given the previous SARS-CoV-2 pandemic and the inherent unpredictability of viral
antigenic drift and shift, preemptive development of diverse neutralizing antibodies targeting …

Adaptive immunity to viral infections requires time to neutralize and clear viruses to resolve
infection. Fast growing and pathogenic viruses are quickly established, are highly …

Substantial evidence supports that Fc-mediated effector functions of anti-spike Abs
contribute to anti–SARS-Cov-2 protection. We have previously shown that two non …

Recent avian influenza outbreaks have heightened global concern over viral threats with the
potential to significantly impact human health. Influenza is particularly alarming due to its …